Diagnostic Specificity of Neurophysiological Endophenotypes in Schizophrenia and Bipolar Disorder
نویسندگان
چکیده
منابع مشابه
Diagnostic specificity of neurophysiological endophenotypes in schizophrenia and bipolar disorder.
BACKGROUND The utility of an endophenotype depends on its ability to reduce complex disorders into stable, genetically linked phenotypes. P50 and P300 event-related potential (ERP) measures are endophenotype candidates for schizophrenia; however, their abnormalities are broadly observed across neuropsychiatric disorders. This study examined the diagnostic efficiency of P50 and P300 in schizophr...
متن کاملNeurophysiological endophenotypes across bipolar and schizophrenia psychosis.
The search for liability genes of the world's 2 major psychotic disorders, schizophrenia and bipolar disorder I (BP-I), has been extremely difficult even though evidence suggests that both are highly heritable. This difficulty is due to the complex and multifactorial nature of these disorders. They encompass several intermediate phenotypes, some overlapping across the 2 psychotic disorders that...
متن کاملTitle: Pattern of Neural Responses to Verbal Fluency Shows Diagnostic Specificity for Schizophrenia and Bipolar Disorder
In the results section, the machine learning classification analysis sensitivity and specificity figures are given but these presumably can be increased or decreased by altering settings during the machine learning. In other words, is the machine learning classification generally taken to optimally balance sensitivity and specificity, or is it prioritising one over the other? Please comment in ...
متن کاملPattern of neural responses to verbal fluency shows diagnostic specificity for schizophrenia and bipolar disorder
BACKGROUND Impairments in executive function and language processing are characteristic of both schizophrenia and bipolar disorder. Their functional neuroanatomy demonstrate features that are shared as well as specific to each disorder. Determining the distinct pattern of neural responses in schizophrenia and bipolar disorder may provide biomarkers for their diagnoses. METHODS 104 participant...
متن کاملNeurophysiological endophenotypes of schizophrenia: the viability of selected candidate measures.
In an effort to reveal susceptibility genes, schizophrenia research has turned to the endophenotype strategy. Endophenotypes are characteristics that reflect the actions of genes predisposing an individual to a disorder, even in the absence of diagnosable pathology. Individual endophenotypes are presumably determined by fewer genes than the more complex phenotype of schizophrenia and would, the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Schizophrenia Bulletin
سال: 2012
ISSN: 0586-7614,1745-1701
DOI: 10.1093/schbul/sbs093